Leptin supplements are concoctions that may help the body with leptin levels; they may help improve the body's use of a protein hormone called leptin, increase the body’s production of it, or actually add leptin into a person’s diet. Supplements commonly are available as pills, capsules or powders. Many people go in search of leptin supplements, expecting them to contain leptin. Most of them do not, however, as the substance is a hormone and may be subject to government prescription-drug regulation in many places. It may be possible, though, to obtain it by prescription if a doctor believes its use is necessary.Leptin is a protein hormone that many people seek in supplement form because it has been associated with weight loss. In fact, leptin has been referred to as the obesity or starvation hormone. The protein is made in a person’s fat cells and travels through the bloodstream to the brain. It is said to let the brain know whether or not there is enough energy in a person’s fat cells. When leptin levels are high enough, the brain is said to believe there is enough stored energy to allow the body to burn calories as it normally would. If leptin levels are too low, however, the body may go into starvation mode, believing it does not have enough energy, slowing metabolism, increasing appetite, and making it harder to lose weight.